The journey of proton therapy for cancer treatment has been transformative, particularly at Massachusetts General Hospital (MGH). The discussion led by Dr. Helen Shih and Dr. Anthony Zietman highlights the advancements in proton therapy at MGH since its initial installation in the 1960s, and the excitement of the first restoration of a proton therapy system. Dr. Shih is the medical director of the Proton Therapy Center, specializing in brain and ocular tumors, while Dr. Zietman, former chief of Radiation Oncology, specializes in genitourinary (GU) oncology and has been using proton therapy since for almost four decades.